Article

Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma

2021-08-04

Abstract excerpt

<h4>Background</h4> Lung cancer is the leading cause of cancer death, partially owing to its extensive heterogeneity. The analysis of intertumor heterogeneity has been limited by an inability to concurrently obtain tissue from synchronous metastases unaltered by multiple prior lines of therapy. <h4>Methods</h4> In order to study the relationship between genomic, epigenomic and T cell repertoire heterogeneity in a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6f5a0ebd-9515-545a-9961-f438903def31
DOI: 10.1101/2021.08.01.21260883

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinomaDOI 10.1101/2021.08.01.21260883Read

Immunogenomic Intertumor Heterogeneity Across Primary and Metastatic Sites in a Patient With Lung AdenocarcinomaSemantic proximity Read

Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma.Semantic proximity Read

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stagesSemantic proximity Read

Genomic and immune heterogeneity of multiple synchronous lung adenocarcinoma at different developmental stages.Semantic proximity Read

Molecular Profiling reveals Tumor Immune Microenvironment Heterogeneity of Concurrent Lung Adenocarcinoma and Squamous Cell Carcinoma in Multiple Primary Lung CancersSemantic proximity Read

TCR Repertoire Intratumor Heterogeneity in Localized Lung Adenocarcinomas: An Association with Predicted Neoantigen Heterogeneity and Postsurgical Recurrence.Semantic proximity Read

Genomic characteristics and immune landscape of super multiple primary lung cancer.Semantic proximity Read

Contraction of T cell richness in lung cancer brain metastasesSemantic proximity Read

Integrated proteogenomic analysis of metastatic thoracic tumors identifies APOBEC mutagenesis and copy number alterations as drivers of proteogenomic tumor evolution and heterogeneitySemantic proximity Read

APOBEC Mutagenesis and Copy-Number Alterations Are Drivers of Proteogenomic Tumor Evolution and Heterogeneity in Metastatic Thoracic TumorsSemantic proximity Read

Heterogeneity of neoantigen landscape between primary lesions and their matched metastases in lung cancerSemantic proximity Read

Non-Genetic Intra-Tumor Heterogeneity Is a Major Predictor of Phenotypic Heterogeneity and Ongoing Evolutionary Dynamics in Lung Tumors.Semantic proximity Read