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Article

Immunogenomic intertumor heterogeneity across primary and metastatic sites in a patient with lung adenocarcinoma.

Journal of experimental & clinical cancer research : CR - 11 May 2022

Chen Runzhe, Li Jun, Fujimoto Junya, Hong Lingzhi, Hu Xin, Quek Kelly, Tang Ming, Mitra Akash, Behrens Carmen, Chow Chi-Wan, Jiang Peixin, Little Latasha D, Gumbs Curtis, Song Xingzhi, Zhang Jianhua, Tan Dongfeng, Heymach John V, Wistuba Ignacio, Futreal P Andrew, Gibbons Don L, Byers Lauren A, Zhang Jianjun, Reuben Alexandre

Abstract excerpt

BACKGROUND: Lung cancer is the leading cause of cancer death, partially owing to its extensive heterogeneity. The analysis of intertumor heterogeneity has been limited by an inability to concurrently obtain tissue from synchronous metastases unaltered by multiple prior lines of therapy. METHODS: In order to study the relationship between genomic, epigenomic and T cell repertoire heterogeneity in a rare autopsy...

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Adenocarcinoma
Adenocarcinoma of Lung
Exome Sequencing
Lung Neoplasms

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PMID: 35546239
DOI: 10.1186/s13046-022-02361-x
PMCID: PMC9092788

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