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Timing and Origins of Local and Distant Metastases in Lung Cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Jul 2021

Tang Wen-Fang, Wu Min, Bao Hua, Xu Yang, Lin Jie-Shan, Liang Yi, Zhang Yu, Chu Xiang-Peng, Qiu Zhen-Bin, Su Jian, Zhang Jia-Tao, Zhang Chao, Xu Fang-Ping, Chen Jing-Hua, Fu Rui, Chen Ying, Yang Tao, Chen Qing-Ke, Wu Ting-Ting, Wu Xue, Shao Yang, Zheng Jian-Tao, Xie Zhi, Lv Zhi-Yi, Dong Song, Wu Yi-Long, Zhong Wen-Zhao

Abstract excerpt

INTRODUCTION: Metastasis is the primary cause of lung cancer-related death. Nevertheless, the underlying molecular mechanisms and evolutionary patterns of lung cancer metastases are still elusive. METHODS: We performed whole-exome sequencing for 40 primary tumors (PTs) and 61 metastases from 47 patients with lung cancer, of which 40 patients had paired PTs and metastases. The PT-metastasis genomic divergence,...

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Cohort Studies
Exome Sequencing
Lung Neoplasms
Lymphatic Metastasis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasm Metastasis

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PMID: 33722707
DOI: 10.1016/j.jtho.2021.02.023

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