Article
Integrated RNA and DNA sequencing reveals early drivers of metastatic breast cancer.
The Journal of clinical investigation - 2 Apr 2018
Siegel Marni B, He Xiaping, Hoadley Katherine A, Hoyle Alan, Pearce Julia B, Garrett Amy L, Kumar Sunil, Moylan Vincent J, Brady Claudia M, Van Swearingen Amanda Ed, Marron David, Gupta Gaorav P, Thorne Leigh B, Kieran Niamh, Livasy Chad, Mardis Elaine R, Parker Joel S, Chen Mengjie, Anders Carey K, Carey Lisa A, Perou Charles M
Abstract excerpt
Breast cancer metastasis remains a clinical challenge, even within a single patient across multiple sites of the disease. Genome-wide comparisons of both the DNA and gene expression of primary tumors and metastases in multiple patients could help elucidate the underlying mechanisms that cause breast cancer metastasis. To address this issue, we performed DNA exome and RNA sequencing of matched primary tumors and...
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