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Article

Evolutionary Characteristics and Immunologic Divergence of Lung and Brain Metastasis Lesions in NSCLC.

Molecular cancer research : MCR - 1 Apr 2023

Xie Tongji, Liu Zhenghao, Li Yan, Wang Shouzheng, Zhai Yixin, Teng Fei, Hao Xuezhi, Wang Yan, Wang Hongyu, Zhang Xin, Wu Xi, Ying Jianming, Li Junling, Zhang Ye, Deng Yuefei, Xing Puyuan

Abstract excerpt

Brain metastases (BM) is one of the main reasons for lung cancer-related deaths but lack prediction methods. Many patients with BMs do not benefit from immunotherapy. A comprehensive genomic analysis of matched primary tumors (PT) and their BM lesions may provide new insight into the evolutionary and immune characteristics. To describe evolutionary features and immune characteristic differences, we analyzed...

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Identifiers

PMID: 36534728
DOI: 10.1158/1541-7786.MCR-22-0474
PMCID: PMC10068444

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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