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Article

Genetic Intratumor Heterogeneity Remodels the Immune Microenvironment and Induces Immune Evasion in Brain Metastasis of Lung Cancer.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Feb 2024

Wang Xin, Bai Hua, Zhang Jiyang, Wang Zhijie, Duan Jianchun, Cai Hongqing, Cao Zheng, Lin Qingtang, Ding Xiaosheng, Sun Yiting, Zhang Wei, Xu Xiaoya, Chen Hao, Zhang Dadong, Feng Xiaoli, Wan Jinghai, Zhang Jianjun, He Jie, Wang Jie

Abstract excerpt

INTRODUCTION: Brain metastasis, with the highest incidence in patients with lung cancer, significantly worsens prognosis and poses challenges to clinical management. To date, how brain metastasis evades immune elimination remains unknown. METHODS: Whole-exome sequencing and RNA sequencing were performed on 30 matched brain metastasis, primary lung adenocarcinoma, and normal tissues. Data from The Cancer Genome...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37717855
DOI: 10.1016/j.jtho.2023.09.276

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