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Single-cell map of diverse immune phenotypes in the metastatic brain tumor microenvironment of nonsmall-cell lung cancer

23 Sept 2024

Abstract excerpt

IntroductionHighlights This is the first time that the immune status of brain metastases from LUAD and breast cancer has been studied through large-scale parallel sequences. We found that tumor stromal cells in lung adenocarcinoma brain metastases have unique transcriptomic characteristics, which distinguish them from primary tumors. The expansion of immunosuppressive macrophages and the lack of activation of T...

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Cancer Cells and Metastasis
Cancer Immunotherapy and Biomarkers
Single-cell and spatial transcriptomics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39311908
DOI: 10.1097/js9.0000000000002088

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