Article
Transfer learning enables prediction of CYP2D6 haplotype function.
PLoS computational biology - 1 Nov 2020
McInnes Gregory, Dalton Rachel, Sangkuhl Katrin, Whirl-Carrillo Michelle, Lee Seung-Been, Tsao Philip S, Gaedigk Andrea, Altman Russ B, Woodahl Erica L
Abstract excerpt
Cytochrome P450 2D6 (CYP2D6) is a highly polymorphic gene whose protein product metabolizes more than 20% of clinically used drugs. Genetic variations in CYP2D6 are responsible for interindividual heterogeneity in drug response that can lead to drug toxicity and ineffective treatment, making CYP2D6 one of the most important pharmacogenes. Prediction of CYP2D6 phenotype relies on curation of literature-derived...
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