Article

Cyrius: accurate <i>CYP2D6</i> genotyping using whole genome sequencing data

2020-05-06

Abstract excerpt

Responsible for the metabolism of 25% of clinically used drugs, CYP2D6 is a critical component of personalized medicine initiatives. Genotyping CYP2D6 is challenging due to sequence similarity with its pseudogene paralog CYP2D7 and a high number and variety of common structural variants (SVs). Here we describe a novel bioinformatics method, Cyrius, that accurately genotypes CYP2D6 using whole-genome sequencing...

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Literature Corpus work: 659349d6-48da-53c6-b8ed-5eceb9a0a647
DOI: 10.1101/2020.05.05.077966

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