Article

Benchmarking analysis of deleterious SNP prediction tools on CYP2D6 enzyme

2019-09-08

Abstract excerpt

The cytochrome P450 family is composed of hemeproteins involved in the metabolic transformation of endogenous and exogenous substances. The CYP2D6 enzyme is responsible for the metabolism of approximately 25% of clinically used drugs and is mainly expressed in the liver. The CYP2D6 gene is known to have a large number of Single Nucleotide Polymorphisms (SNPs) and the majority of them do not present clinical conse...

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Literature Corpus work: 8ef24953-bff5-583a-b01a-fd1754b475b0
DOI: 10.1101/760298

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