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Article

Toward predicting CYP2D6-mediated variable drug response from CYP2D6 gene sequencing data.

Science translational medicine - 21 Jul 2021

van der Lee Maaike, Allard William G, Vossen Rolf H A M, Baak-Pablo Renée F, Menafra Roberta, Deiman Birgit A L M, Deenen Maarten J, Neven Patrick, Johansson Inger, Gastaldello Stefano, Ingelman-Sundberg Magnus, Guchelaar Henk-Jan, Swen Jesse J, Anvar Seyed Yahya

Abstract excerpt

Pharmacogenomics is a key component of personalized medicine that promises safer and more effective drug treatment by individualizing drug choice and dose based on genetic profiles. In clinical practice, genetic biomarkers are used to categorize patients into *-alleles to predict CYP450 enzyme activity and adjust drug dosages accordingly. However, this approach leaves a large part of variability in drug response...

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Identifiers

PMID: 34290055
DOI: 10.1126/scitranslmed.abf3637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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