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Article

Cyrius: accurate CYP2D6 genotyping using whole-genome sequencing data.

The pharmacogenomics journal - 1 Apr 2021

Chen Xiao, Shen Fei, Gonzaludo Nina, Malhotra Alka, Rogert Cande, Taft Ryan J, Bentley David R, Eberle Michael A

Abstract excerpt

Responsible for the metabolism of ~21% of clinically used drugs, CYP2D6 is a critical component of personalized medicine initiatives. Genotyping CYP2D6 is challenging due to sequence similarity with its pseudogene paralog CYP2D7 and a high number and variety of common structural variants (SVs). Here we describe a novel bioinformatics method, Cyrius, that accurately genotypes CYP2D6 using whole-genome sequencing...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33462347
DOI: 10.1038/s41397-020-00205-5
PMCID: PMC7997805

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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