Article

Homology-Based Variant-Effect Predictors Break Down on Cytochrome P450 Pharmacogenes <sup>*</sup>

2026-08-05

Abstract excerpt

Cytochrome P450 (CYP) enzymes metabolize roughly three-quarters of clinically used drugs; genetic variation in these enzymes is a leading source of interindividual differences in drug response. Predicting a variant’s functional effect is therefore critical, yet the consequences of most CYP variants remain unknown. Many state-of-the-art variant-effect predictors rest on a homology-based paradigm that scores variant...

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Literature Corpus work: 3dcbde88-b7ff-5c65-bda7-9af4c852b892
DOI: 10.64898/2026.07.30.741616

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