Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Full-gene haplotypes refine CYP2D6 metabolizer phenotype inferences.

International journal of legal medicine - 1 Jul 2018

Wendt Frank R, Sajantila Antti, Moura-Neto Rodrigo S, Woerner August E, Budowle Bruce

Abstract excerpt

CYP2D6 is a critical pharmacogenetic target, and polymorphisms in the gene region are commonly used to infer enzyme activity score and predict resulting metabolizer phenotype: poor, intermediate, extensive/normal, or ultrarapid which can be useful in determining cause and/or manner of death in some autopsies. Current genotyping approaches are incapable of identifying novel and/or rare variants, so CYP2D6 star...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cytochrome P-450 CYP2D6
Share to Haplotypes
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Pharmacogenetics

Share to Phenotype

Share to Polymorphism, Genetic

Source

Identifiers

PMID: 29075918
DOI: 10.1007/s00414-017-1709-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Full-gene haplotypes refine CYP2D6 metabolizer phenotype inferences.PMID 29075918Read ↗

Prediction of CYP2D6 phenotype from genotype across world populations.Semantic proximity Read ↗

Comprehensive Allele Genotyping in Critical Pharmacogenes Reduces Residual Clinical Risk in Diverse Populations.Semantic proximity Read ↗

Keeping pace with CYP2D6 haplotype discovery: innovative methods to assign function.Semantic proximity Read ↗

Sequencing the CYP2D6 gene: from variant allele discovery to clinical pharmacogenetic testing.Semantic proximity Read ↗

Complexities of CYP2D6 gene analysis and interpretation.Semantic proximity Read ↗

Constellation: a tool for rapid, automated phenotype assignment of a highly polymorphic pharmacogene, CYP2D6, from whole-genome sequencesSemantic proximity Read ↗

Characterization of CYP2D6 Pharmacogenetic Variation in Sub-Saharan African Populations.Semantic proximity Read ↗

Predicted activity of UGT2B7, ABCB1, OPRM1, and COMT using full-gene haplotypes and their association with the CYP2D6-inferred metabolizer phenotype.Semantic proximity Read ↗

Interethnic variability of CYP2D6 alleles and of predicted and measured metabolic phenotypes across world populations.Semantic proximity Read ↗

Cyrius: accurate <i>CYP2D6</i> genotyping using whole genome sequencing dataSemantic proximity Read ↗

Genetic ancestral patterns in<i>CYP2D6</i>alleles: structural variants, rare variants, and clinical associations in 479,144 UK Biobank genomesSemantic proximity Read ↗

BCyrius: An Upgraded Version of Cyrius for Accurate CYP2D6 Genotyping From Short-Read Sequencing Data.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.