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BCyrius: An Upgraded Version of Cyrius for Accurate CYP2D6 Genotyping From Short-Read Sequencing Data.

Pharmacology research & perspectives - 1 Feb 2025

Halman Andreas, Conyers Rachel

Abstract excerpt

Pharmacogenomics is a field of personalized medicine that aims to tailor drug dosing based on the genetics of an individual. The polymorphic and complex CYP2D6 gene is important to analyze because of its role in the metabolism of approximately a quarter of all drugs. Several bioinformatic tools have been developed to genotype CYP2D6 from short-read sequencing data. Among these, Cyrius, a tool specifically...

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PMID: 39901590
DOI: 10.1002/prp2.70065
PMCID: PMC11791018

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