Article
Keeping pace with CYP2D6 haplotype discovery: innovative methods to assign function.
Pharmacogenomics - 1 Mar 2022
Brown Karen E, Staples Jack W, Woodahl Erica L
Abstract excerpt
The discovery of haplotypes with unknown or uncertain function in the CYP2D6 pharmacogene is outpacing the capabilities of traditional in vitro and in vivo approaches to characterize their function. This challenge will undoubtedly grow as pharmacogenomic research becomes more inclusive of globally diverse populations. As accurate phenotypic assignment is paramount to the utility of pharmacogenomics,...
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