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Article

Cartilaginous fish class II genes reveal unprecedented old allelic lineages and confirm the late evolutionary emergence of DM.

Molecular immunology - 1 Dec 2020

Almeida Tereza, Gaigher Arnaud, Muñoz-Mérida Antonio, Neves Fabiana, Castro L Filipe C, Flajnik Martin F, Ohta Yuko, Esteves Pedro J, Veríssimo Ana

Abstract excerpt

Cartilaginous fish (chimaeras, rays and sharks) are the most basal extant jawed vertebrates with an adaptive immune system based on the Major Histocompatibility Complex (MHC). Despite being a key taxon in the evolution of vertebrate adaptive immunity, no comprehensive characterization of MHC class II genes has been undertaken for the group. We performed extensive bioinformatic searches on a taxonomically diverse...

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Identifiers

PMID: 33126081
DOI: 10.1016/j.molimm.2020.10.003
PMCID: PMC8010645

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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