Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The most primitive vertebrates with jaws possess highly polymorphic MHC class I genes comparable to those of humans.

Immunity - 1 Dec 1997

Okamura K, Ototake M, Nakanishi T, Kurosawa Y, Hashimoto K

Abstract excerpt

We report the isolation and extensive analysis of highly polymorphic MHC class I genes from sharks (Triakis scyllia), which belong to the most primitive vertebrate group with jaws, the cartilaginous fish. Predicted complete peptide-binding domains showed retention of the critical amino acid residues that would interact with antigenic peptide termini and revealed extensive allelic polymorphisms comparable to those...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Amino Acid Sequence
Share to Base Sequence

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Blotting, Southern

Share to Chromosome Mapping

Share to Molecular Sequence Data

Share to Polymorphism, Genetic

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 9430223
DOI: 10.1016/s1074-7613(00)80396-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The most primitive vertebrates with jaws possess highly polymorphic MHC class I genes comparable to those of humans.PMID 9430223Read ↗

Comparative genomic analysis of the MHC: the evolution of class I duplication blocks, diversity and complexity from shark to man.Semantic proximity Read ↗

Cartilaginous fish class II genes reveal unprecedented old allelic lineages and confirm the late evolutionary emergence of DM.Semantic proximity Read ↗

An Illumina approach to MHC typing of Atlantic salmon.Semantic proximity Read ↗

Molecular characterization of major histocompatibility complex class II alleles in wild tiger salamanders (Ambystoma tigrinum).Semantic proximity Read ↗

Characterization of a divergent non-classical MHC class I gene in sharks.Semantic proximity Read ↗

Improved high-throughput MHC typing for non-model species using long-read sequencing.Semantic proximity Read ↗

Advances in the Evolutionary Understanding of MHC Polymorphism.Semantic proximity Read ↗

Extensive diversification of MHC in Chinese giant salamanders Andrias davidianus (Anda-MHC) reveals novel splice variants.Semantic proximity Read ↗

Antigen-presenting genes and genomic copy number variations in the Tasmanian devil MHCSemantic proximity Read ↗

Two ancient allelic lineages at the single classical class I locus in the Xenopus MHC.Semantic proximity Read ↗

Classical MHC class I genes composed of highly divergent sequence lineages share a single locus in rainbow trout (Oncorhynchus mykiss).Semantic proximity Read ↗

Polymorphism of duck MHC class molecules.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.