Article
Comparative genomic analysis of the MHC: the evolution of class I duplication blocks, diversity and complexity from shark to man.
Immunological reviews - 1 Dec 2002
Kulski Jerzy K, Shiina Takashi, Anzai Tatsuya, Kohara Sakae, Inoko Hidetoshi
Abstract excerpt
The major histocompatibility complex (MHC) genomic region is composed of a group of linked genes involved functionally with the adaptive and innate immune systems. The class I and class II genes are intrinsic features of the MHC and have been found in all the jawed vertebrates studied so far. The MHC genomic regions of the human and the chicken (B locus) have been fully sequenced and mapped, and the mouse MHC...
Topics
- Animals
- Biological Evolution
- Birds
- Chromosome Mapping
- Fishes
- Gene Duplication
- Genes, MHC Class I
- Genes, MHC Class II
- Genetic Variation
- Genomics
- Humans
- Major Histocompatibility Complex
- Mammals
- Primates
- Sharks
- Species Specificity