Article
Two ancient allelic lineages at the single classical class I locus in the Xenopus MHC.
Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 1999
Flajnik M F, Ohta Y, Greenberg A S, Salter-Cid L, Carrizosa A, Du Pasquier L, Kasahara M
Abstract excerpt
Unlike all other vertebrates examined to date, there is only one detectable class I locus in the Xenopus MHC. On the bases of a nearly ubiquitous and high tissue expression, extensive polymorphism, and MHC linkage, this gene is of the classical or class Ia type. Sequencing analysis of class Ia cDNAs encoded by eight defined MHC haplotypes reveals two very old allelic lineages that perhaps emerged when humans and...
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