Article
Long-lived dichotomous lineages of the proteasome subunit beta type 8 (PSMB8) gene surviving more than 500 million years as alleles or paralogs.
Molecular biology and evolution - 1 Oct 2012
Tsukamoto Kentaro, Miura Fumi, Fujito Naoko T, Yoshizaki Goro, Nonaka Masaru
Abstract excerpt
On an evolutionary time scale, polymorphic alleles are believed to have a short life, persisting at most tens of millions of years even under long-term balancing selection. Here, we report highly diverged trans-species dimorphism of the proteasome subunit beta type 8 (PSMB8) gene, which encodes a catalytic subunit of the immunoproteasome responsible for the generation of peptides presented by major...
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