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The Immunoglobulins: New Insights, Implications, and Applications

17 Dec 2019

Abstract excerpt

Immunoglobulins (Igs), as one of the hallmarks of adaptive immunity, first arose approximately 500 million years ago with the emergence of jawed vertebrates. Two events stand out in the evolutionary history of Igs from cartilaginous fish to mammals: ( a) the diversification of Ig heavy chain (IgH) genes, resulting in Ig isotypes or subclasses associated with novel functions, and ( b) the diversification of...

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PMID: 31846352
DOI: 10.1146/annurev-animal-021419-083720

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