Antibodies of sharks: revolution and evolution

doi:10.1111/j.1600-065x.1998.tb01256.x

Article

Antibodies of sharks: revolution and evolution

1 Dec 1998

Abstract excerpt

The combinatorial immune response is restricted to jawed vertebrates with cartilaginous fishes being the lowest extant species to have the mechanism for diversification and an extensive panoply of immunoglobulins, T-cell receptors and MHC products. Here, we review the molecular events of the "big bang" or rapid evolutionary appearance of the functionally complete combinatorial immune system coincident with the...

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