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Article

Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging.

Aging - 26 Oct 2020

Luciano-Mateo Fedra, Cabré Noemí, Baiges-Gaya Gerard, Fernández-Arroyo Salvador, Hernández-Aguilera Anna, Elisabet Rodríguez-Tomàs Elisabet, Arenas Meritxell, Camps Jordi, Menéndez Javier A, Joven Jorge

Abstract excerpt

Injection of tissues with senescent cells induces changes that mimic aging, and this process is delayed in mice engineered to eliminate senescent cells, which secrete proinflammatory cytokines, including C-C motif chemokine ligand 2 (Ccl2). Circulating levels of Ccl2 correlate with age, but the impact of Ccl2 on tissue homeostasis has not been established. We generated an experimental model by crossbreeding mice...

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Identifiers

PMID: 33104522
DOI: 10.18632/aging.104154
PMCID: PMC7655213

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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