Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chemokine C-C motif ligand 2 overexpression drives tissue-specific metabolic responses in the liver and muscle of mice.

Scientific reports - 20 Jul 2020

Luciano-Mateo Fedra, Cabré Noemí, Fernández-Arroyo Salvador, Baiges-Gaya Gerard, Hernández-Aguilera Anna, Rodríguez-Tomàs Elisabet, Muñoz-Pinedo Cristina, Menéndez Javier A, Camps Jordi, Joven Jorge

Abstract excerpt

Chemokine (C-C motif) ligand 2 (CCL2) has been associated with chronic metabolic diseases. We aimed to investigate whether Ccl2 gene overexpression is involved in the regulation of signaling pathways in metabolic organs. Biochemical and histological analyses were used to explore tissue damage in cisgenic mice that overexpressed the Ccl2 gene. Metabolites from energy and one-carbon metabolism in liver and muscle...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy
Share to Biopsy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chemokine CCL2

Share to Energy Metabolism

Share to Metabolic Networks and Pathways

Share to Muscles

Share to Organ Specificity

Source

Open in PubMed Open full text

Identifiers

PMID: 32686726
DOI: 10.1038/s41598-020-68769-7
PMCID: PMC7371894

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chemokine C-C motif ligand 2 overexpression drives tissue-specific metabolic responses in the liver and muscle of mice.PMID 32686726Read ↗

Systemic overexpression of C-C motif chemokine ligand 2 promotes metabolic dysregulation and premature death in mice with accelerated aging.Semantic proximity Read ↗

Dietary pyruvate targets cytosolic phospholipase A2 to mitigate inflammation and obesity in miceSemantic proximity Read ↗

A dietary ketone ester mitigates histological outcomes of NAFLD and markers of fibrosis in high-fat diet fed mice.Semantic proximity Read ↗

Enhanced catabolism of branched-chain amino acids uncouples anti-inflammatory and antioxidant functions in liver macrophagesSemantic proximity Read ↗

Molecular Profiling Reveals a Common Metabolic Signature of Tissue FibrosisSemantic proximity Read ↗

Targeted expression of uncoupling protein 2 to mouse liver increases the susceptibility to lipopolysaccharide/galactosamine-induced acute liver injury.Semantic proximity Read ↗

Inhibition of the oxygen sensor PHD2 in the liver improves survival in lactic acidosis by activating the Cori cycle.Semantic proximity Read ↗

Hypertrophic cardiomyopathy and dysregulation of cardiac energetics in a mouse model of biliary fibrosis.Semantic proximity Read ↗

Mitochondrial Pyruvate Carrier Inhibition Attenuates Hepatic Stellate Cell Activation and Liver Injury in a Mouse Model of Metabolic Dysfunction-associated Steatotic Liver DiseaseSemantic proximity Read ↗

Tumor growth affects the metabonomic phenotypes of multiple mouse non-involved organs in an A549 lung cancer xenograft model.Semantic proximity Read ↗

Myeloid ATP Citrate Lyase Regulates Macrophage Inflammatory Responses In Vitro Without Altering Inflammatory Disease Outcomes.Semantic proximity Read ↗

Tissue-Specific and Interorgan Metabolic Reprogramming Maintains Tolerance to SepsisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.