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Small extracellular vesicles from young plasma reverse age-related functional declines by improving mitochondrial energy metabolism

16 Apr 2024

Abstract excerpt

Recent investigations into heterochronic parabiosis have unveiled robust rejuvenating effects of young blood on aged tissues. However, the specific rejuvenating mechanisms remain incompletely elucidated. Here we demonstrate that small extracellular vesicles (sEVs) from the plasma of young mice counteract pre-existing aging at molecular, mitochondrial, cellular and physiological levels. Intravenous injection of...

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PMID: 38627524
DOI: 10.1038/s43587-024-00612-4

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