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Human skeletal muscle aging atlas

15 Apr 2024

Abstract excerpt

Skeletal muscle aging is a key contributor to age-related frailty and sarcopenia with substantial implications for global health. Here we profiled 90,902 single cells and 92,259 single nuclei from 17 donors to map the aging process in the adult human intercostal muscle, identifying cellular changes in each muscle compartment. We found that distinct subsets of muscle stem cells exhibit decreased ribosome...

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PMID: 38622407
DOI: 10.1038/s43587-024-00613-3

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