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Senescent myoblasts exhibit an altered exometabolome that is linked to senescence-associated secretory phenotype signaling.

American journal of physiology. Cell physiology - 1 Feb 2025

Kamal Michael, Shanmuganathan Meera, Kroezen Zachery, Joanisse Sophie, Britz-McKibbin Philip, Parise Gianni

Abstract excerpt

Cellular senescence has been implicated in the aging-related dysfunction of satellite cells, the resident muscle stem cell population primarily responsible for the repair of muscle fibers. Despite being in a state of permanent cell cycle arrest, these cells remain metabolically active and release an abundance of factors that can have detrimental effects on the cellular microenvironment. This phenomenon is known...

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PMID: 39726265
DOI: 10.1152/ajpcell.00880.2024

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