Article
GNAS mutation detection in circulating cell-free DNA is a specific predictor for intraductal papillary mucinous neoplasms of the pancreas, especially for intestinal subtype.
Scientific reports - 20 Oct 2020
Hata Tatsuo, Mizuma Masamichi, Motoi Fuyuhiko, Omori Yuko, Ishida Masaharu, Nakagawa Kei, Hayashi Hiroki, Morikawa Takanori, Kamei Takashi, Furukawa Toru, Unno Michiaki
Abstract excerpt
Pancreatic cystic neoplasms (PCNs) are a heterogeneous group with varying risks of malignancy. To explore the clinical utility of liquid biopsy in cyst type classification, we analyzed the GNAS/KRAS mutations in circulating cell-free DNA (cfDNA) obtained from 57 patients with histologically diagnosed PCNs, including 34 with intraductal papillary mucinous neoplasms (IPMNs) and compared the mutant allele prevalence...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.