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Article

Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas.

Expert review of molecular diagnostics - 1 Mar 2015

Frampton Adam E, Stebbing Justin, Gall Tamara M H, Silver Benjamin, Jiao Long R, Krell Jonathan

Abstract excerpt

Intraductal papillary mucinous neoplasms (IPMNs) of the pancreas have a risk of malignant transformation following an adenoma-carcinoma sequence. Surgical resection is often required, especially for main pancreatic duct IPMNs (MD-IPMNs). There is an urgent need for novel biomarkers to reliably differentiate IPMNs from more benign pancreatic cysts and therefore avoid unnecessary surgery. DNA sequencing has...

Read the complete abstract on PubMed

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Share to Biomarkers, Tumor
Share to GNAS gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to GTP-Binding Protein alpha Subunits, Gs

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Share to Pancreatic Neoplasms

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Source

Identifiers

PMID: 25656048
DOI: 10.1586/14737159.2015.1002771

Genes

GNAS
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas.PMID 25656048Read ↗

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