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Article

GNAS and KRAS Mutations Define Separate Progression Pathways in Intraductal Papillary Mucinous Neoplasm-Associated Carcinoma.

Journal of the American College of Surgeons - 1 May 2015

Tan Marcus C, Basturk Olca, Brannon A Rose, Bhanot Umesh, Scott Sasinya N, Bouvier Nancy, LaFemina Jennifer, Jarnagin William R, Berger Michael F, Klimstra David, Allen Peter J

Abstract excerpt

BACKGROUND: Intraductal papillary mucinous neoplasms (IPMN) are being increasingly recognized as important precursors to pancreatic adenocarcinoma. Elucidation of the genetic changes underlying IPMN carcinogenesis may improve the diagnosis and management of IPMN. We sought to determine whether different histologic subtypes of IPMN would exhibit different frequencies of specific genetic mutations. STUDY DESIGN:...

Topics

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Adenocarcinoma, Mucinous
Carcinoma, Pancreatic Ductal
Carcinoma, Papillary
Chromogranins
GTP-Binding Protein alpha Subunits, Gs

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Oncogene Proteins

Pancreatic Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 25840541
DOI: 10.1016/j.jamcollsurg.2014.11.029
PMCID: PMC4409519

Genes

GNAS
KRAS
RNF43

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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