Article
Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.
Science translational medicine - 20 Jul 2011
Wu Jian, Matthaei Hanno, Maitra Anirban, Dal Molin Marco, Wood Laura D, Eshleman James R, Goggins Michael, Canto Marcia I, Schulick Richard D, Edil Barish H, Wolfgang Christopher L, Klein Alison P, Diaz Luis A, Allen Peter J, Schmidt C Max, Kinzler Kenneth W, Papadopoulos Nickolas, Hruban Ralph H, Vogelstein Bert
Abstract excerpt
More than 2% of the adult U.S. population harbors a pancreatic cyst. These often pose a difficult management problem because conventional criteria cannot always distinguish cysts with malignant potential from those that are innocuous. One of the most common cystic neoplasms of the pancreas, and a bona fide precursor to invasive adenocarcinoma, is called intraductal papillary mucinous neoplasm (IPMN). To help...
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