Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia.

doi:10.1136/gutjnl-2016-313586

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Article

Preoperative next-generation sequencing of pancreatic cyst fluid is highly accurate in cyst classification and detection of advanced neoplasia.

Gut - 1 Dec 2018

Singhi Aatur D, McGrath Kevin, Brand Randall E, Khalid Asif, Zeh Herbert J, Chennat Jennifer S, Fasanella Kenneth E, Papachristou Georgios I, Slivka Adam, Bartlett David L, Dasyam Anil K, Hogg Melissa, Lee Kenneth K, Marsh James Wallis, Monaco Sara E, Ohori N Paul, Pingpank James F, Tsung Allan, Zureikat Amer H, Wald Abigail I, Nikiforova Marina N

Abstract excerpt

OBJECTIVE: DNA-based testing of pancreatic cyst fluid (PCF) is a useful adjunct to the evaluation of pancreatic cysts (PCs). Mutations in KRAS/GNAS are highly specific for intraductal papillary mucinous neoplasms (IPMNs) and mucinous cystic neoplasms (MCNs), while TP53/PIK3CA/PTEN alterations are associated with advanced neoplasia. A prospective study was performed to evaluate preoperative PCF DNA testing....

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Identifiers

PMID: 28970292
DOI: 10.1136/gutjnl-2016-313586
PMCID: PMC6241612

Genes

GNAS
KRAS
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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