Article
Next-Generation Sequencing Revealed TP53 Mutations to Be Malignant Marker for Intraductal Papillary Mucinous Neoplasms That Could Be Detected Using Pancreatic Juice.
Pancreas - 1 Jan 2000
Takano Shinichi, Fukasawa Mitsuharu, Kadokura Makoto, Shindo Hiroko, Takahashi Ei, Hirose Sumio, Maekawa Shinya, Mochizuki Kunio, Kawaida Hiromichi, Itakura Jun, Katoh Ryohei, Fujii Hideki, Sato Tadashi, Enomoto Nobuyuki
Abstract excerpt
OBJECTIVES: The aims of this study were to identify the genetic mutations associated with malignant intraductal papillary mucinous neoplasms (IPMNs) and evaluate the possibility of detecting mutations in pure pancreatic juice by next-generation sequencing. METHODS: Resected tissues were collected from 50 patients with IPMN, and pure pancreatic juice samples were collected from 19 patients who had a resection. The...
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