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Article

Deep sequencing of cancer-related genes revealed GNAS mutations to be associated with intraductal papillary mucinous neoplasms and its main pancreatic duct dilation.

PloS one - 1 Jan 2014

Takano Shinichi, Fukasawa Mitsuharu, Maekawa Shinya, Kadokura Makoto, Miura Mika, Shindo Hiroko, Takahashi Ei, Sato Tadashi, Enomoto Nobuyuki

Abstract excerpt

BACKGROUND: To clarify the genetic mutations associated with intraductal papillary mucinous neoplasms (IPMN) and IPMN-related pancreatic tumours, we conducted cancer-related gene profiling analyses using pure pancreatic juice and resected pancreatic tissues. METHODS: Pure pancreatic juice was collected from 152 patients [nine with a normal pancreas, 22 with chronic pancreatitis (CP), 39 with pancreatic ductal...

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Topics

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Share to Adenocarcinoma, Mucinous
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Papillary

Share to Chromogranins

Share to GTP-Binding Protein alpha Subunits, Gs

Share to Magnetic Resonance Angiography

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Source

Open in PubMed Open full text

Identifiers

PMID: 24897499
DOI: 10.1371/journal.pone.0098718
PMCID: PMC4045804

Genes

GNAS
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

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Research trail→

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Deep sequencing of cancer-related genes revealed GNAS mutations to be associated with intraductal papillary mucinous neoplasms and its main pancreatic duct dilation.PMID 24897499Read ↗

GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas.Semantic proximity Read ↗

Whole-exome sequencing uncovers frequent GNAS mutations in intraductal papillary mucinous neoplasms of the pancreas.Semantic proximity Read ↗

GNAS mutation detection in circulating cell-free DNA is a specific predictor for intraductal papillary mucinous neoplasms of the pancreas, especially for intestinal subtype.Semantic proximity Read ↗

Activating mutations of GNAS and KRAS in cystic fluid can help detect intraductal papillary mucinous neoplasms of the pancreas.Semantic proximity Read ↗

Clinical significance of GNAS mutation in intraductal papillary mucinous neoplasm of the pancreas with concomitant pancreatic ductal adenocarcinoma.Semantic proximity Read ↗

Next-Generation Sequencing Revealed TP53 Mutations to Be Malignant Marker for Intraductal Papillary Mucinous Neoplasms That Could Be Detected Using Pancreatic Juice.Semantic proximity Read ↗

Molecular analysis of EUS-acquired pancreatic cyst fluid for KRAS and GNAS mutations for diagnosis of intraductal papillary mucinous neoplasia and mucinous cystic lesions: a systematic review and meta-analysis.Semantic proximity Read ↗

Preoperative GNAS and KRAS testing in the diagnosis of pancreatic mucinous cysts.Semantic proximity Read ↗

GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs".Semantic proximity Read ↗

Recurrent GNAS mutations define an unexpected pathway for pancreatic cyst development.Semantic proximity Read ↗

Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype.Semantic proximity Read ↗

Targeted next-generation sequencing of cancer genes dissects the molecular profiles of intraductal papillary neoplasms of the pancreas.Semantic proximity Read ↗

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