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Article

GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas.

Virchows Archiv : an international journal of pathology - 1 Jun 2015

Hosoda Waki, Sasaki Eiichi, Murakami Yoshiko, Yamao Kenji, Shimizu Yasuhiro, Yatabe Yasushi

Abstract excerpt

In contrast to pancreatic ductal adenocarcinomas (PDAs), intraductal papillary mucinous neoplasms (IPMNs) frequently harbour GNAS mutations. To characterise GNAS-mutated pancreatic carcinomas, we examined mutations of GNAS and KRAS in 290 pancreatic adenocarcinomas and 77 pancreatic intraepithelial neoplasias (PanINs). In 64 % (39/61) of IPMNs and 37 % (11/30) of IPMN-associated adenocarcinomas, a GNAS mutation...

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Share to Adenocarcinoma, Mucinous
Share to Carcinoma, Pancreatic Ductal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Papillary

Share to Chromogranins

Share to GTP-Binding Protein alpha Subunits, Gs

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Source

Identifiers

PMID: 25796395
DOI: 10.1007/s00428-015-1751-6

Genes

GNAS
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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GNAS mutation is a frequent event in pancreatic intraductal papillary mucinous neoplasms and associated adenocarcinomas.PMID 25796395Read ↗

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