Article
GNAS sequencing identifies IPMN-specific mutations in a subgroup of diminutive pancreatic cysts referred to as "incipient IPMNs".
The American journal of surgical pathology - 1 Mar 2014
Matthaei Hanno, Wu Jian, Dal Molin Marco, Shi Chanjuan, Perner Sven, Kristiansen Glen, Lingohr Philipp, Kalff Jörg C, Wolfgang Christopher L, Kinzler Kenneth W, Vogelstein Bert, Maitra Anirban, Hruban Ralph H
Abstract excerpt
Incipient intraductal papillary mucinous neoplasms (IPMNs) are poorly described subcentimeter pancreatic cysts with papillae and mucin similar to IPMNs. They are larger than pancreatic intraepithelial neoplasia but do not meet the cutoff size for IPMNs (≥ 1 cm). GNAS codon 201 mutations are hallmark genetic alterations of IPMNs. Hence, we sought to determine the GNAS status of incipient IPMNs to better classify...
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