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Article

APOE2 is associated with longevity independent of Alzheimer’s disease

19 Oct 2020

Abstract excerpt

Although the ε2 allele of apolipoprotein E ( APOE2 ) benefits longevity, its mechanism is not understood. The protective effects of the APOE 2 on Alzheimer’s disease (AD) risk, particularly through their effects on amyloid or tau accumulation, may confound APOE2 effects on longevity. Herein, we showed that the association between APOE2 and longer lifespan persisted irrespective of AD status, including its...

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PMID: 33074098
DOI: 10.7554/elife.62199

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