Article
ApoE gene and exceptional longevity: Insights from three independent cohorts.
Experimental gerontology - 1 May 2014
Garatachea Nuria, Emanuele Enzo, Calero Miguel, Fuku Noriyuki, Arai Yasumichi, Abe Yukiko, Murakami Haruka, Miyachi Motohiko, Yvert Thomas, Verde Zoraida, Zea Ma Ascensión, Venturini Letizia, Santiago Catalina, Santos-Lozano Alejandro, Rodríguez-Romo Gabriel, Ricevuti Giovanni, Hirose Nobuyoshi, Rábano Alberto, Lucia Alejandro
Abstract excerpt
The ApoE gene is associated with the risk of Alzheimer or cardiovascular disease but its influence on exceptional longevity (EL) is uncertain. Our primary purpose was to determine, using a case-control design, if the ApoE gene is associated with EL. We compared ApoE allele/genotype frequencies among the following cohorts: cases (centenarians, most with 1+ major disease condition; n=163, 100-111years) and healthy...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.