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Article

Association of APOE e2 genotype with Alzheimer's and non-Alzheimer's neurodegenerative pathologies.

Nature communications - 18 Sept 2020

Goldberg Terry E, Huey Edward D, Devanand D P

Abstract excerpt

The apolipoprotein E (APOE) gene contains both the major common risk variant for late onset Alzheimer's disease (AD), e4, and the major neuroprotective variant, e2. Here we examine the association of APOE e2 with multiple neurodegenerative pathologies, leveraging the NACC v. 10 database of 1557 brains that included 130 e2 carriers and 679 e4 carriers in order to examine potential neuroprotective effects. For...

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Identifiers

PMID: 32948752
DOI: 10.1038/s41467-020-18198-x
PMCID: PMC7501268

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