Article
Exceptionally low likelihood of Alzheimer's dementia in APOE2 homozygotes from a 5,000-person neuropathological study.
Nature communications - 3 Feb 2020
Reiman Eric M, Arboleda-Velasquez Joseph F, Quiroz Yakeel T, Huentelman Matthew J, Beach Thomas G, Caselli Richard J, Chen Yinghua, Su Yi, Myers Amanda J, Hardy John, Paul Vonsattel Jean, Younkin Steven G, Bennett David A, De Jager Philip L, Larson Eric B, Crane Paul K, Keene C Dirk, Kamboh M Ilyas, Kofler Julia K, Duque Linda, Gilbert John R, Gwirtsman Harry E, Buxbaum Joseph D, Dickson Dennis W, Frosch Matthew P, Ghetti Bernardino F, Lunetta Kathryn L, Wang Li-San, Hyman Bradley T, Kukull Walter A, Foroud Tatiana, Haines Jonathan L, Mayeux Richard P, Pericak-Vance Margaret A, Schneider Julie A, Trojanowski John Q, Farrer Lindsay A, Schellenberg Gerard D, Beecham Gary W, Montine Thomas J, Jun Gyungah R
Abstract excerpt
Each additional copy of the apolipoprotein E4 (APOE4) allele is associated with a higher risk of Alzheimer's dementia, while the APOE2 allele is associated with a lower risk of Alzheimer's dementia, it is not yet known whether APOE2 homozygotes have a particularly low risk. We generated Alzheimer's dementia odds ratios and other findings in more than 5,000 clinically characterized and neuropathologically...
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