Article

<i>APOE2</i> promotes longevity independent of Alzheimer’s disease

2020-08-31

Abstract excerpt

<h4>Objective</h4> Although apolipoprotein E ( APOE ) allele associates with longevity, its mechanism is not understood. The protective effects of APOE 2 and the deleterious effects of APOE4 on Alzheimer’s disease (AD) risk may confound APOE effects on longevity. <h4>Methods</h4> We analyzed a large number of subjects from the National Alzheimer’s Coordinating Center (NACC), and animal models expressing hum...

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Literature Corpus work: 11a811ff-3d34-544a-91b2-5ae2053a4182
DOI: 10.1101/2020.08.31.255141

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