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The impact of APOE genotype on survival: Results of 38,537 participants from six population-based cohorts (E2-CHARGE)

29 Jul 2019

Abstract excerpt

BACKGROUND: Apolipoprotein E is a glycoprotein best known as a mediator and regulator of lipid transport and uptake. The APOE-ε4 allele has long been associated with increased risks of Alzheimer's disease and mortality, but the effect of the less prevalent APOE-ε2 allele on diseases in the elderly and survival remains elusive. METHODS: We aggregated data of 38,537 individuals of European ancestry (mean age 65.5...

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PMID: 31356640
DOI: 10.1371/journal.pone.0219668

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