Article
A De Novo Designed Esterase with p-Nitrophenyl Acetate Hydrolysis Activity.
Molecules (Basel, Switzerland) - 13 Oct 2020
Li Guanlin, Xu Li, Zhang Houjin, Liu Junjun, Yan Jinyong, Yan Yunjun
Abstract excerpt
Esterases are a large family of enzymes with wide applications in the industry. However, all esterases originated from natural sources, limiting their use in harsh environments or newly- emerged reactions. In this study, we designed a new esterase to develop a new protocol to satisfy the needs for better biocatalysts. The ideal spatial conformation of the serine catalytic triad and the oxygen anion hole at the...
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