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Article

Engineering L-threonine transaldolase and a chaperone assisted cascade for the efficient biosynthesis of L-threo-p-methylsulfonylphenylserine.

International journal of biological macromolecules - 1 Apr 2026

Wang Chen, Liu Jiyuan, Yang Wenhao, Wang Hua, Miao Jincheng, Sun Hongxu, Chang Yanhong, Luo Hui

Abstract excerpt

The efficient asymmetric synthesis of L-threo-p-methylsulfonylphenylserine (L-threo-4-MTPS) is frequently hindered by the limited catalytic efficiency of natural transaldolases and severe feedback inhibition caused by acetaldehyde accumulation. In this study, we identified a novel L-threonine transaldolase from Chitiniphilus eburneus (CeLTTA) via systematic genome mining. To overcome its kinetic limitations,...

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PMID: 41881214
DOI: 10.1016/j.ijbiomac.2026.151614

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