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Article

Preimmune Control of the Variance of TCR CDR-B3: Insights Gained From Germline Replacement of a TCR Dβ Gene Segment With an Ig D H Gene Segment.

Frontiers in immunology - 1 Jan 2020

Khass Mohamed, Levinson Michael, Schelonka Robert L, Kapoor Pratibha, Burrows Peter D, Schroeder Harry W

Abstract excerpt

We have previously shown that the sequence of the immunoglobulin diversity gene segment (D H ) helps dictate the structure and composition of complementarity determining region 3 of the immunoglobulin heavy chain (CDR-H3). In order to test the role of germline D sequence on the diversity of the preimmune TCRβ repertoire of T cells, we generated a mouse with a mutant TCRβ DJC locus wherein the Dβ2-Jβ2 gene segment...

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Source

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Identifiers

PMID: 33042119
DOI: 10.3389/fimmu.2020.02079
PMCID: PMC7518465

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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