A biological consequence of variation in the site of D-JH gene rearrangement.

doi:10.1038/311376a0

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Article

A biological consequence of variation in the site of D-JH gene rearrangement.

Nature - 1 Jan 2000

Pollok B A, Kearney J F, Vakil M, Perry R P

Abstract excerpt

One mechanism which generates diversity in immunoglobulin variable (V) regions is flexibility in the site of recombination among the constituent genetic elements. Within a specific antibody family (that is, a particular VH-VL combination), variability in V-D-J rearrangement not only leads to sequ...

Topics

Animals
Antibodies, Monoclonal
Base Sequence
Genes
Genetic Variation
Immunoglobulin Heavy Chains
Immunoglobulin Idiotypes
Immunoglobulin Light Chains
Immunoglobulin Variable Region
Mice
Mice, Inbred BALB C

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