Article
A biological consequence of variation in the site of D-JH gene rearrangement.
Nature - 1 Jan 2000
Pollok B A, Kearney J F, Vakil M, Perry R P
Abstract excerpt
One mechanism which generates diversity in immunoglobulin variable (V) regions is flexibility in the site of recombination among the constituent genetic elements. Within a specific antibody family (that is, a particular VH-VL combination), variability in V-D-J rearrangement not only leads to sequence diversity at the boundary of the juxtaposed genes, but also enables the total length of the third...
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