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Article

HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence.

Immunogenetics - 1 Feb 2016

Wang Yuge, Kapoor Pratibha, Parks Robert, Silva-Sanchez Aaron, Alam S Munir, Verkoczy Laurent, Liao Hua-Xin, Zhuang Yingxin, Burrows Peter, Levinson Michael, Elgavish Ada, Cui Xiangqin, Haynes Barton F, Schroeder Harry

Abstract excerpt

Complementarity Determining Region 3 of the immunoglobulin (Ig) H chain (CDR-H3) lies at the center of the antigen-binding site where it often plays a decisive role in antigen recognition and binding. Amino acids encoded by the diversity (DH) gene segment are the main component of CDR-H3. Each DH has the potential to rearrange into one of six DH reading frames (RFs), each of which exhibits a characteristic amino...

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Share to Antibody Formation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to env Gene Products, Human Immunodeficiency Virus

Share to Epitope Mapping

Share to HIV Envelope Protein gp120

Share to HIV Envelope Protein gp41

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Source

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Identifiers

PMID: 26687685
DOI: 10.1007/s00251-015-0890-x
PMCID: PMC4729650

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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