Article
MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4+ T cells.
Proceedings of the National Academy of Sciences of the United States of America - 16 Jun 2020
Logunova Nadezhda N, Kriukova Valeriia V, Shelyakin Pavel V, Egorov Evgeny S, Pereverzeva Alina, Bozhanova Nina G, Shugay Mikhail, Shcherbinin Dmitrii S, Pogorelyy Mikhail V, Merzlyak Ekaterina M, Zubov Vasiliy N, Meiler Jens, Chudakov Dmitriy M, Apt Alexander S, Britanova Olga V
Abstract excerpt
T cell maturation and activation depend upon T cell receptor (TCR) interactions with a wide variety of antigenic peptides displayed in a given major histocompatibility complex (MHC) context. Complementarity-determining region 3 (CDR3) is the most variable part of the TCRα and -β chains, which govern interactions with peptide-MHC complexes. However, it remains unclear how the CDR3 landscape is shaped by individual...
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