Article
Heavy Chain CDR 3 and Junctional Length Biases in Human Antibody Repertoires Associated with Heavy and Light Chain Germline Utilization
2019-06-10
Abstract excerpt
Antibody variable domain sequence diversity is generated by recombination of germline segments. The third complementarity-determining region of the heavy chain (CDR H3) is the region of highest sequence diversity and is formed by the joining of heavy chain V H , D H and J H germline segments combined with random nucleotide trimming and additions between these segments. We show that CDR H3 length distribution is...
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Identifiers and source
- Literature Corpus work
- f4b59be3-447c-52f4-95bf-9d4a1e69aef0
- DOI
- 10.1101/664714